According to Main Line Today, it takes talent and tenacity to tackle the world’s most pressing problems, and Chester County has its hands full of daring entrepreneurs, including several that headlined Main Line Today’s recently published list of the 15 Most Daring Entrepreneurs.

VenatoRx partners Christopher Burns, Daniel Pevear and Luigi Xerri boast a five-lab Malvern operation of scientists pioneering next-generation antibiotics that kill today’s nastiest germs.

“If an experiment doesn’t work, we learn from it and take that knowledge to the next experiment,” Burns said in the feature. “It’s those failures that create our successes.”

HubBub Coffee Owner Drew Crockett is a visionary who left Wall Street and worried his parents to spark a “craft coffee” craze on the University of Pennsylvania campus, in Radnor and beyond.

Husband-wife duo and LifeSplice Pharma Co-Founders Gordon J. Lutz and Melanie Tallent are Malvern molecular and neurobiologists whose specialties combined to provide an advantage in today’s hottest area of medicine, and they’re now pursuing breakthroughs for muscular dystrophy, Dravet syndrome, epilepsy and ALS.

“She’s about 100 times smarter than me,” Lutz said. “Melanie is working on the brain, I’m working on the drug, and the drug is best with the brain. Bingo.”

Relay Network Co-Founders Steve Gillin, Matt Gillin and Paul Raden are chasing a new corporate communications technology in Radnor on the heels of a $200 million prepaid card tech buyout.

“Competition isn’t necessarily another company but another solution that feels similar to the customer that works faster and better,” Matt Gillin said in the article. “We make our technology better by failing quickly, learning, adapting and moving forward — advancing the ball.”

Walnut St. Labs Founder and CEO Chris Dima stumbled into an “ecosystem” of idea generation, shared work space and an entrepreneurial incubator in West Chester by leading where no one else wanted to go.

“I want to nurture tech entrepreneurship in the suburbs — and Chester County, specifically,” he said. “That’s who I am, and that’s the story I want to tell.”

Theraplay Founder and President Lisa Mackell converted a Malvern elementary school into a pediatric physical therapy center before she garnered a full scholarship for a mini-MBA at West Chester University and lured her husband into helping expand to six centers, including in West Chester and Landenberg.

“I only knew that kids would benefit from having therapy centers customized to target their needs,” she said. “Speech, occupational, physical therapy — kids need all of those treatments, delivered by pediatric specialists.”

SparkNET Technologies Partner Jonathon Beschen brainstormed the Wayne tech firm that pioneered service for equity and launched the Liberty Valley Initiative to incubate tech entrepreneurs.

“I don’t know if people outside the tech industry realize how much is happening on the Main Line,” he said in the article. “But they soon will.”

Finally, Zoomi Chairman and CEO James Walker of Malvern has created a transformative e-learning technology that can “predict your performance, individualize content in real time and optimize social learning. It’s about measuring learning in the workplace and linking that to business outcomes,” he said.

Read more about each of Chester County’s boldest entrepreneurs and others across the region in Main Line Today here.